ISBN: 978-81-8487-567-6 
Publication Year:   2017
Pages:   480
Binding:   Hard Back

Although the entire evolution of life is an adaptation right from the coming-together of the elements and reaching to human life as we know today, the realization of the adaptation biology as a discipline is relatively recent. Furthermore, subcellular basis of gradual adaptation of body systems in stressful conditions is still a greate mystery of biology. The present book attempts to fill that gap. It is known that such an adaptation not only increases tolerance of the body to that given stress but also to other challenges. A complete knowledge of this cross protection needs to be defined and exp;oited to improve patient care. The book includes chapters describing subcellular adaptations; adaptation to different stresses as well as to lifestyle and environment. Although for an easy reading the information has been grouped under the sub-heading: Current Trends, the book represents a common continuum of adaptations. The therapeutic value of the understanding of the science of adaptation has also been described in several chapters. Examples of cross adaptations are also provided, where repeated exposure to one stinulus may ptentialyy be used in the treatment as well as prophylaxis of different diseases. The present book will be of great interest to all biologists, physiologists, pharmacologists and physicians interested in the application of the biology of adaptation in the improvement of health.

Preface / Acknowledgements / Contributing Authors / Subcellular Adaptations: Mitochondrial Signalind in Hypoxia andits relation with Succinate-Dependent Processes: Transcriptional Activities of HIF-1? and Expression of GPR-91 Receptor / Significance of Mitochondrial Individuality / Phosphodiesterase-5 Inhibition and Cardioprotection in Type 2 Diabetes: role of Mitochondria / Intracellular Sodium Overload in Hereditary Cardiomyopathy / Cysteine-rich Proteins in Cardiovascular Disease / Thyroid Homones-Induced Adaptive Responses in Cardiac Redox Environment / Myocardial Changes after Mediastinal Irradiation in Rats: Molecular Mechansisms and Potential Targets to Minimize the Adverse Effects / Burns in Animal Models: Pathophysiology, Technique, and Utility of Basic Science Research in Burns / Doxorubicin Induces Cell Death of Ventricular Myocytes by a Mechanism Involving Bnip3 / Interplay Between Genes of Vascular Homeostasis Modulates Hypertension / Protective Role of Akt1-S1177 Against Stroke / ADAPTATIONS TO DIFFERENT STRESSES: New Developments in Lower Limb Prosthesis Design: Effects on Residual Limb Volume, Pistoning, Skin Tolerance, Skin Contact Pressures, and Hemodynamics / The Effects of Lower Body Positive Pressure and Walking on Fluid Turnover in Human Legs / Leg Length and the Evolution of Human Stature: Insights from Evolutionary Studies of Tail Length in Snakes / Positive Physiological Adaptation Effects of Shinrin-yoku / Regulatory Role of the Glutathione System in Coupled Redox Processes of Brain Adaptation to Hypoxia / Prevention of Cerebrovascular and Neurodegenerative Disorders by Adaptation to Hypoxia in Alzheimer’s Disease / Antistress and Cardioprotective Effectsof Xenon / Adaptation to Intermittent Normobaric Hypoxia: Forty-Five Years of Experimental and Clinical Investigations / Tempol and Melatonin Blunt Antiarrhythmic Effect of Chronic Intermittent Hypoxia in Rats / The Common Misinterpretation About the Fat-Reducing Outcome of Exercise Training: The Fat Burning Theory ? / Thirsty and Energetic – The Hydration Knowledge and Energy Drink consumption of Youth Engaged in Competitive Sport in Singapore / LIFESTYLE AND ENVIRONMENT IN ADAPTATIONS: Distribution of the Cannabinoid Type 1 Receptor and Ocular Dominance Plasticity in the Primary Visual Cortex / Nociception: A Dual Effect of Ouabain Targeting / Effect of Secoisolariciresinol Diglucoside on Antioxidants Response in an in vitro Cardiac Iron Overland Condition / KIR2.1-Dendra2: A New Tool to Study Drug-Induced Ion Channel Trafficking Defects / A Review on Evaluation of Pimpinella tirupatiensis as a Possible Adaptive Medicine to Control STZ Induced Diabetic Complications in Liver and Cardiac Tissues / Resveratrol Inhibits the Growth of Prostate Cancer Cells Through Decreasing Androgen Receptor Phosphorylation and Protien Stability / Effects of Calorie Restriction or Swimming Enduance Training on Cardiac Telomerase Activity in Obese Insulin-Resistant OLETF rats / Proposed New Lymphology Combined with Lymph Physiology, Immunology and Oncology / Differences in Cardiovascular Gender Based Trends in Canada / Gravity Change and Muscle/Bone Relationship / Sexual Dimorphism in the Preoptic Area: An Adaptive Outcome to Environment / Index.