Gonadal and Nongonadal Actions of Gonadotropins offers latest information on the structure and function of the gonadotropins, their signal transduction, and action at cellular and molecular levels. The topics include endometriosis, premature ovarian failure, PCOS, cryptorchidism, genetic and intersex disorders, assisted reproduction, immune functions, bone remodeling, dementia and Alzheimer’s disease, and cancers, in relation to these molecules.

Preface / What is New in LH and hCG Research and how it can be Clinically Useful? / Gonadotropin Structure and Functions: Structural and Functional Determinants in the Extracellular Domain of Follicle Stimulating Hormone Receptor / The Proteome as Source of Regulatory Oligopeptides / Novel Drugs for Infertility Treatment / Rescue of Ovarian Function with Gonadotropins: Role of FSH Heterogeneity / Signal Transduction: Mitochondrial A-Kinase Anchoring Proteins and the Compartmentalization of PKA in Steroidogenesis / Insulin-like Growth Factor-1 and Follicle Stimulating Hormone Synergy in Regulation of Steroidogenic Gene(s) in Granulosa Cells / Receptors: Luteinizing Hormone Receptor Expression in Human Adrenal Glands / Bone Phenotypes in Cases of Over or Missing Gonadotropin Action / Extragonadal LH/hCG Actions: Evidence for and Against from Genetically Modified Mice / Gonadal Functions: Gonadotropin Receptors in Uterus, their Distribution and Functional Relevance / Hypoxic Modulation of LH Action on the MA-10 Cells / Endocrine and Paracrine Control of Leydig Cell Functions in Reptiles / Role of Human Chorionic Gonadotropins in Cryptorchidism / Pregnancy: Novel Regulatory Actions of hCG in Human Non-Pregnant and Pregnant Uterus / hCG Supplementation in Recurrent Miscarriage: Pros and Cons / Neoplasia: Immunological Approaches Against Human Chorionic Gonadotropin for Control of Fertility and Advanced Stage Cancers Expressing Ectopically hCG / Infertility and Ovarian Cancer: A Review / Possible Roles of Gonadotropins in Endometriosis / Gonadotropins, Ovulation and Ovarian Cancer / Drug Delivery: Hecate-Chorionic Gonadotropin ß Conjugate for Luteinizing Hormone Receptor Expressing Endocrine Tumor Treatment / Regulation of Ovarian Function: Possible Application of Nanotechnology / Development and Ageing: Functional Consequences of Gonadrotropin Signaling in the Brain During Development, Adulthood and Senescence / The Role of Luteinizing Hormone in Alzheimer’s Disease / Genetics: Genetics of Premature Ovarian Failure (POF): Genes Affecting Gonadotropin Oogenesis / Hormonal Treatment for Disorders of Sexual Differentiation / Second Trimester Antenatal Screening for Down’s Syndrome / Do Gonadotropins Used for Ovarian Stimulation in Assisted Reproduction Cause Increase in Chromosome Aneuploidy, Chromosome Mosaicism and Skewed Sex Ratio in Embryos? / Assisted Reproductive Techniques: Recombinant Gonadotrophins vs Urinary Gonadotrophins - A Clinical Perspective / Role of Recombinant and Urinary Gonadotropins for Controlled Ovarian Stimulation in ART Cycles / Role of LH in the Etiology of PCOS: Intra-Ovarian Defect in Human Polycystic Ovary Syndrome Patients without Peripheral Insulin Resistance / Index.

Graduate Students, Researchers and Professionals in Reproductive Biology